All layout grids can be designed in two ways: symmetric or asymmetric.
Symmetric grids follow a center line. The vertical margins are equal to each other, as are the horizontal ones. Columns in a symmetric layout are also the same width.
In an asymmetric layout, both margins and columns can be different from one another. It is important to always look for balance when using an asymmetric layout.

manuscript grid
A Word document or a presentation template will always have a manuscript grid.
Manuscript grids in a text document separate the header, the footer and the space on the edges (margins). The manuscript layout creates a rectangle inside the page (format), like a bounding box for text.
The rest of the pages will follow the same measurements. It’s good practice to keep the manuscript grid consistent inside one document design.

column grid
Column grids are used to organize elements into columns.
Magazines use column grids to place the text in easy-to-read sections.
Column grids are used inside websites as well, like in online newspapers or blogs.
Column grids can have as little as two columns or as many as six or more, but that is not very common.