The design should be based on a grid. Have an explanation for each element you place in the design.
The design should be balanced (symmetrical or asymmetrical balance)
The design should be visually pleasing and interesting.
Start with sketches using the worksheet.
Think how you'll break the text from your label into text boxes, text ribbons, what shapes (if any) you want to add, etc.
Then open Illustrator.
The design should be 6"x6"
Place a 2" grid over the area. Place 1/8" margins inside each 2" square. Subdivide squares into 1" parts.
How you do it? You can actually create it using Rectangle tool. You can apply and modify the grid, or use the guides.
Then start executing you best design sketch. There are limitless layout possibilities for the grid design. You can use each square for your elements, few squares for an element, circles, curves, and other non-square shapes should be aligned with the grid guides.